2. i can afford the money for the chance of early detection. Many cancers are symptomatic only in the latter stages. It does not hurt to check.
And anyway, you have to die of something so for me cancer would just be a sign that time's up.
This has been my experience. And I’ve had oncologists echo exactly this. In the words of one: MRIs find too much.
The CT and the PET/CT are the gold standards for finding cancer, finding recurrences, and staging cancer. The trouble is the radiation dose.
MRI provides very inconclusive results. You’ll see something but it’ll be unclear what it is. And often what you see is not even visible on a CT. Or it’s visible on a PET/CT and is showing metabolic activity indicating its cancer.
MRIs are great for certain things like herniated disks in your back. They suck at cancer.
But scanning frequently is overwhelmingly good for the patient. The problem is the doctors. Imagine two possibilities. 1. You scan every six months and a doctor reviews your scans but never tells you anything no matter what 2. You scan every six months and a doctor reviews your scans and only tells you results if you have an obviously growing mass that has a probability greater than 95% of being cancerous
Obviously #2 is better for the patient than #1, but #1 is equivalent to never testing if you ignore cost.
So the actual reason we don't have effect frequent scans combined with effective diagnostic techniques is cost, and doctors cope with this reality by saying clearly wrong things about "over diagnosis". It's a local minimum of the payer/provider dynamic that has nothing to do with scans per se.
Maybe I don't want to look for cancer right now but if I spend $1,000 every 5 years to take an image for later use... isn't that useful?
> One study in 2020 found that 95% of asymptomatic patients had some type of "abnormal" finding, but just 1.8% of these findings were indeed cancer.
So a bit less than 1.8% of the time in this study
> Prenuvo's recent Polaris Study followed 1,011 patients for at least one year following a whole-body MRI scan. Of these patients, 41 had biopsies. More than half of the 41 were diagnosed with cancer.
That's 2.0%
Note that this doesn't mean that 1.7~2.0% of people have cancer without knowing it. It could be more:
> A negative scan doesn’t mean you’re disease-free. Some cancers and conditions simply aren’t visible yet or aren’t reliably detected on a one-time full-body MRI."
But also perhaps less, in a way:
> "You're finding something that never would have caused you any problem in your life, and in cancer, we call that overdiagnosis," Vickers says.
But now you've found it you pretty much have to remove it, which has significant quality of life implications.
Let everyone who wants to pay get their scans! But don’t make me pay for you
One caveat is that regular PET isn't so good in the brain - there is so much metabolic activity that everything glows. So I get an MRI Brain to go with my regular full body PET/CT (cancer 5 years ago with recurrence 18 months later, currently NED).
My father is a part of "full body PET scan every 3 years" program as part of post - cancer treatment, and it worked twice: early detected lung and prostate tumors, both removed.
Doctor warned me up front that the odds the images find something that looks weird is high but not to panic because of how many false positives there are when looking inside someone’s body.
While I am happy to report they didn’t find anything serious, I do take slight offense to the following at the top of my results:
Last name, First name: Unremarkable
(Kidding of course but still got a chuckle out of me)
It found a weird spot on me that turned out to a pancreatic rest.
The only reason we did the scans were because we were making a significant life decision that we didn’t want to have to backtrack if either got diagnosed with cancer within a year . We knew nothing was guaranteed but we wanted to do some tests.
Wrong? I understand MRIs are the standard for certain types of cancer like brain and spinal tumors.
With respect to whole body MRI they can be less effective because it’s not optimized, accuracy can be traded for area.
But as a general statement MRIs do not suck at cancer.
Here, you have a tool with a ~100% false positive rate, so if we start administering it to everyone, it will almost certainly cost lives. Botched biopsies, unnecessary treatments, other complications. Not to mention the huge cost that would divert money from other welfare programs. So you need to show that when it actually detects something, it saves at least as many lives. And I doubt that's the case.
(for some people that question may not apply, of course, but at a population level it does, and we have population-level questions about effective use of MRI time.). And if there's something better, you should spend it on that and then ask the question _again_. So it could be that getting a whole-body MRI is something like $30k down the list of best ways to spend money for improved health.
I'm not sure what the best use of $1k is from a health standpoint is, just noting that it's good to have a comparator.
These treatments are wonderful and it is great that they exist. But many people fail to understand the difference in terms of pretest probability, etc.
I can absolutely see the heavy psychological impact pending biopsy results may have. People are quick to discount these issues when you raise them as a concern, but only if they never went through this stress themselves
In a full body situation, they are looking for mets, and the uptake of radioactive sugar by the tumors will let a PET scan find them.
You don't need to show that it's possible to avoid false positives. That's doctors being irrational.
You only need to show that it's possible to build a diagnostic system that's better than no testing, and I have shown that already
If you make a test that always returns true, it would also meet that criteria.
Is it though? Isn't it possible you could be early-detecting something serious that is much easier to treat now vs when symptoms appear?
Spending 1k on a gym membership and more fresh vegetables would be a pretty high return on investment, if one isn't in shape and eating healthy already.
Age is a big factor in the with/of cancer factor. If someone is 80 years old then there's good chance it won't be cancer that kills them (assuming they aren't already in a late stage).
But if you are 40 and you have cancer, there's a good chance you'll die of that cancer if it's left untreated.
I'm personally of the opinion that cancer screening should happen earlier for younger people and less frequently for older people. Like, if you hit 80, there's really basically no reason to screen for cancer.
No offense for me, just confusion. One of the status reports started as follows:
> OptionOfT is a very pleasant 36-year-old gentleman 6 weeks status post left anterior total hip arthroplasty done by Dr. _ on _.
I asked my wife whether I was particularly friendly (I sometimes fail to adjust my demeanor in certain situations).
She said: nah, they write that for everybody.
So if you have abnormal findings in 10% of patients that merit follow-up scans, you can trivially do a series of 3-4 scans without affecting the overall cost too much.
Doctors simply need to get out of the headspace where MRIs are extremely scarce tools of last resort and treat them like we treat blood tests.
Nothing in medicine comes for free—everything is a tradeoff.
Rohin Francis does a good video on it, which you don't have to watch because it has references underneath you can click straight through to (the video is good though): https://youtu.be/yNzQ_sLGIuA
I am frustrated by this because it seems obvious to me that "more data == better" but I guess it makes sense if you think of the scans as having high amounts of noise, and us having a poor understanding of the system we're monitoring (this never happens in tech, of course :)).
It could be. It could also be the cade that you undergo invasive surgery for something that would have never caused you problems within your life. The problem is that cancer isn‘t cancer. Even if it originates from the same tissue, some tumors behave very different from others.
Treating MRIs the way we treat blood tests would almost certainly result in huge numbers of needless invasive procedures.
A lot of this however is how it is discussed with the patient. Discussions about the likelihood of there being a real issue when something is seen need to be clear and informative without being alarming. 'We did a routine scan and these often show transient artifacts that turn out to be nothing, but in an abundance of caution we want to do a followup' is totally different than 'we saw something we are concerned about and need to do a followup'. How things are messaged really matters.

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Picture this: At your annual physical with your primary care provider, you also receive a full-body scan and a more extensive panel of bloodwork. Just to make sure that you are 100% fine, nothing is wrong with you, you can go on your way and not worry a second longer about your health. Or if there is something, even tiny, now you can fix it before it gets worse.
Sounds perfect, right? That's a future many envision thanks to a health and wellness longevity culture brimming with innovation aimed at keeping us healthier for longer.
"Sometimes, even if we have a great lifestyle, it's important to get a baseline, because we don't really understand," says Andrew Lacy, founder and CEO of full-body MRI company Prenuvo. "Everyone's genetics are unique. And some people can be fit and have liver problems or fit and have sort of inflammatory bowel problems. And knowing this is just really helpful."
As exciting as it seems, others in the medical community are skeptical – particularly about full-body MRIs. Dr. Manjiri Dighe, Professor of Radiology at the University of Washington School of Medicine, says that "whole body MRI is in its clinical infancy. While it is non-invasive and highly sensitive, it lacks the large-scale longitudinal data needed to prove that it saves more lives than it complicates through overdiagnosis." With low availability and high cost, for the average person, it remains a luxury item not an "evidence-based medical necessity." The tests range from several hundred to several thousand dollars, depending on which sections of the body are scanned, and are not covered by insurance.
Research shows these test often find something, but much less often find actual disease. One study in 2020 found that 95% of asymptomatic patients had some type of "abnormal" finding, but just 1.8% of these findings were indeed cancer. Research has varied on just how many incidental findings occur from these tests.
Prenuvo's recent Polaris Study followed 1,011 patients for at least one year following a whole-body MRI scan. Of these patients, 41 had biopsies. More than half of the 41 were diagnosed with cancer. Of these cancers, 68% didn't have targeted screening tests and 64% were localized when detected. The company says it finds possibly life-threatening conditions in 1 in 20 people.
What's the average person to do?
Dr. Daniel Sodickson, chief medical scientist at Function and adjunct professor in the Department of Radiology at New York University, has been working on MRI and other imaging technology for nearly 30 years. Over the last five to 10 years, he began asking himself more and more: Why do these remarkable machines he and his colleagues devoted their lives to building and improving only help patients when they're sick?
"They're remarkable tools to guide therapy, to diagnose and so on," he says. "But by and large, we use them after people have had symptoms or some other signs of disease, and in too many cases, it's too late."
He shifted his thinking to focus more on proactive medicine, and he began advising MRI company Ezra (later acquired by Function, where he now works full-time). At Function, in addition to preventative, full-body MRI screening to detect early stage cancers, aneurysms and abnormalities, patients can also seek out extensive panels of blood tests to interpret all their results with proper perspective.
"It's all about context," he says. "And I think that's what addresses a lot of the concerns about false positive rates and downstream tests." That's where a lot of criticism comes for preventative testing. How often are you performing unnecessary tests on low-risk individuals, when whatever you find wouldn't have developed into anything serious? And how much is that costing someone financially and emotionally over time?
Andrew Vickers, attending research methodologist at Memorial Sloan Kettering Cancer Center, knows some people will find real problems with whole-body MRIs. But is there evidence to show it's doing more harm than good? "You're finding something that never would have caused you any problem in your life, and in cancer, we call that overdiagnosis," Vickers says. The harder we look for cancers, the more we will over-diagnose them. And if someone is over-diagnosed, gets a biopsy and develops an infection, that's a direct harm.
"These unnecessary additional exams and treatments would further burden our healthcare system, which is already overburdened," Dighe adds. "For the general asymptomatic population, the statistical probability of a false positive is significantly higher than the probability of finding a curable, life-threatening cancer."
Humans crave reassurance. And when social media algorithms feed that reassurance, it's easy to see why these tests seem smart to try.
More than 87% of influencer posts on social media about such tests (including full-body MRI, multi-cancer early detection tests and more) offered a positive spin, according to a JAMA study published in February 2025; about 84% were overt promotions.
A closer look at numbers shows "the confirmed cancer detection rate is approximately 1.6% in general screening populations, with 11% receiving treatment triggered by whole-body MRI findings when including both malignant and benign conditions requiring intervention," says Dr. Mina S. Makary, associate professor of radiology at The Ohio State University Wexner Medical Center, referencing a 2025 European Radiology study. "The fear of 'missing something' often feels larger than the actual statistical risk," Makary adds. "Also, we need to recognize that false reassurance is possible. A negative scan doesn’t mean you’re disease-free. Some cancers and conditions simply aren’t visible yet or aren’t reliably detected on a one-time full-body MRI."
Lacy argues the test "just gives you so much runway and options to affect the trajectory of that disease" if you indeed have something in an early stage. He remembers giving away a free scan at a hospital, the winner a 38-year-old nurse. The machine found lung cancer. She had never smoked.
Sodickson envisions a future where we will monitor our health through blood tests, imaging and wearables even more closely. An early warning system built in that tells us what's wrong before our symptoms do. For now, he doesn't recommend getting a scan "then trying to scramble and make sense of all the data yourselves. What's important to think about is making this more of a repeating habit." Ideally, costs will continue to go down over time for this kind of testing. Insurance may cover them someday.
"Most of those things that could be anxiety-provoking go away or are much less concerning, if you get a second scan and you see that things aren't changed," he adds. "So most of the anxiety someone lives with can be dealt with by just getting another time point and seeing a trend rather than seeing a snapshot."
These tests also serve as warning signs for less serious but still concerning conditions like spinal degeneration. "Just being able to tell someone in their 20s, hey, you got to watch out here, because, you shouldn't really have this level of degeneration at your age," Lacy says, forces them to watch their posture and pay attention.
Sodickson has had many MRIs in his life, including Ezra scans and a Function blood test. Surprises awaited him, too. But "I feel like I actually have someone looking out for me now, rather than just blindly going through my life and maybe one day waking up with with a disease I never knew I had a susceptibility to."
While these tests could be life-saving for those with certain conditions, for many clinicians to widely recommend them, they'd want to see cost-effectiveness and a true mortality benefit, Dighe says. "In medicine, 'more information' is not always 'better information.'"
Lacy is betting on the future. "The health system can and will adapt to early detection, and I think it's sad to suggest the alternative, which is we don't know how to handle this, and we're not sure we can adapt, and therefore we shouldn't allow patients to have more information about their health."
No matter what you decide for yourself, consult a licensed medical professional for advice.
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